PTCB PTCE Pharmacy Technician Certification (CPhT) Exam Exam Practice Test

AZ-Pakrefers to theAzithromycin 5-day therapy pack, which is commonly prescribed forbacterial infectionssuch as respiratory infections. The standard dosing regimen follows a"loading dose" strategyto quickly reach effective drug levels in the body:

Day 1:Taketwo tablets (500 mg total).

Days 2-5:Takeone tablet (250 mg) daily.

This regimen helps achieverapid therapeutic concentrationswhile maintaining effectiveness over five days.

A. 1 tablet PO on the current day, then 1 PO daily for 4 days→ Incorrect; aloading dose (2 tablets on Day 1)is required for proper drug efficacy.

B. 1 tablet PO on the current day, then 1 PO daily for 5 days→ Incorrect; the Z-Pak is a5-day regimen, not 6 days.

D. 3 tablets PO on the current day, then 1 PO every other day for 6 days→ Incorrect; this isnot a standard dosing regimenfor azithromycin.

Other Answer Choices Explained:References:

FDA Drug Monograph for Azithromycin (Z-Pak)

Lexicomp Drug Guide – Azithromycin Dosing

PTCB PTCE Exam Content Outline (Pharmacology – Infectious Disease Medications)

Risedronate (Actonel) is a bisphosphonate used for osteoporosis.

It can causehypocalcemia (low calcium levels)byinhibiting bone resorption.

Patients must take it witha full glass of water and remain upright for 30 minutesto preventesophageal irritation.

????Reference:FDA Bisphosphonate Warnings, PTCB Drug Counseling Guidelines.

Cleaning counting trays removes medication residue to prevent cross-contamination, especially with penicillin or sulfa drugs.

????Reference:ISMP Pharmacy Cleaning and Contamination Prevention Guidelines.

When entering prescription information into a pharmacy computer system,using leading zeros helps prevent medication dosing errorsby clearly specifying the correct dose.

What Are Leading Zeros?Aleading zerois azero placed before a decimal pointto prevent misinterpretation.

✅Correct:0.5 mg(clearly means half a milligram)

❌Incorrect:.5 mg(could be mistaken for 5 mg, leading to a10× overdose).

A. Allergies❌→Important, butnot directly related to dosing errors.

C. Insurance Information❌→Unrelated to medication dosing safety.

D. Contraindications❌→Relevant to medication selection, but not specific to preventing dosing errors.

ISMP Best Practices for Medication Safety– Recommends usingleading zerosto prevent dosing mistakes.

Joint Commission "Do Not Use" List– Warns against missing leading zeros in prescriptions.

PTCB PTCE Exam Content Outline– Covers prescription entry and error prevention strategies.

Why Not the Other Options?Key References:

Formula: Dose ÷ Concentration = Volume (mL)

30 mg ÷ 20 mg/mL = 1.5 mL

????Reference:PTCB Calculation Guide, Pharmacy Dosage Conversions.

Phenytoin (Dilantin)is ananticonvulsantthatstabilizes neuronal membranesbyblocking sodium channels, reducing seizure activity.

Used forepilepsy, tonic-clonic seizures, and status epilepticus.

Why Other Options Are Incorrect:

A. Clonidine?❌Used forhypertension and ADHD, NOT seizures.

B. Atomoxetine?❌Used forADHD, NOT seizures.

C. Guanfacine?❌Used forhypertension and ADHD, NOT seizures.

????Reference:FDA Drug Label for Phenytoin, Epilepsy Foundation Guidelines.

Comprehensive and Detailed Step-by-Step Explanation:

To calculate the percentage ofpsylliumin the final preparation:

Formula:

A math equations with numbers and symbols Description automatically generated with medium confidence

Sincepsylliummakes up500 gout of1000 g (1 kg)of the bulk laxative, it accounts for50%of the total formulation.

????Reference:

USP <795>Compounding Standards

PTCE ExamPharmaceutical Calculations

Comprehensive and Detailed Step-by-Step Explanation:

If a prescriber fails to include a quantity on a prescription, it is considered a prescribing error. Pharmacists and pharmacy technicians must contact the prescriber for clarification.

????Explanation of Answer Choices:

✅D. Prescribing → Correct. The prescriber made the error by omitting critical information.

❌A. Administration → Incorrect. This refers to errors in how the patient takes the medication.

❌B. Dispensing → Incorrect. This refers to pharmacy errors in filling the prescription.

❌C. Dosage → Incorrect. A dosage error occurs when the wrong dose is prescribed or administered.

????Reference:

ISMP Medication Error Guidelines

PTCB Exam: Types of Medication Errors

Enbrel (etanercept) is a biologic that must be stored in the refrigerator (2°C–8°C or 36°F–46°F).

????Reference:Manufacturer Storage Guidelines, USP Refrigeration Standards.

St. John's Wort (Hypericum perforatum)is anherbal supplementcommonly used formild to moderate depression.

Containshypericin and hyperforin, which may increaseserotonin, dopamine, and norepinephrinelevels.

Often used as analternative treatment for depression, but not FDA-approved for this indication.

Hasserious drug interactions, including withantidepressants (SSRIs, SNRIs), warfarin, oral contraceptives, and cyclosporine.

(A) Immune enhancer❌Incorrect – Not primarily used to boost the immune system.

(B) Mild antidepressant✅Correct – Used for mild depression.

(C) Antioxidant❌Incorrect – While it has some antioxidant properties, this is not its primary use.

(D) Antihypertensive❌Incorrect – It does not lower blood pressure.

National Center for Complementary and Integrative Health (NCCIH) – St. John’s

MedlinePlus – St. John's Wort Drug

PTCB Exam Content Outline – Herbal Supplements & Drug Interactions

How St. John’s Wort Works:Analysis of Answer Choices:References for Pharmacy Technicians:

Comprehensive and Detailed Step-by-Step Explanation:

Stock rotation (First In, First Out - FIFO)ensures thatolder medications are used before newer stock, reducing expired medication dispensing.

????Explanation of Answer Choices:✅C. Rotating stock on a regular basis→Correct.FIFO method reduces waste and errors.❌A. Verifying each lot number→ Incorrect.Lot numbers do not indicate expiration dates.❌B. Using the newest medications first→ Incorrect.Older stock should be used first.❌D. Using the last in, first out method→ Incorrect.Opposite of the correct practice.

????Reference:

USP <1079>: Medication Storage and Inventory Control

PTCB Exam: Inventory Management

Vaccines come in different strengths for adults and children, and mix-ups can lead to underdosing or overdosing.

Storing pediatric and adult vaccines separately within the refrigerator reduces the risk of errors.

Example:PediatricCOVID-19 vaccines (lower dose) and adult doses look similar but have different concentrations.

Why Other Options Are Incorrect:

A. Repackaging?❌Against CDC and USP <797> guidelines, which require vaccines to remain in their original packaging.

B. Ordering from different manufacturers?❌Not practical; most pharmacies use a single supplier for consistency.

D. Automated dispensing systems?❌Not always available for vaccines.

????Reference:CDC Vaccine Storage & Handling Guidelines, ISMP Vaccine Safety Best Practices.

Comprehensive and Detailed Step-by-Step Explanation:

To find how muchmentholis needed:

(0.25100)×600g=1.5g=1500mg\left( \frac{0.25}{100} \right) \times 600 g = 1.5 g = 1500 mg(1000.25​)×600g=1.5g=1500mg

????Explanation of Answer Choices:✅C. 1500 mg→Correct.0.25% of 600 g = 1500 mg.❌A. 15 mg→ Incorrect.Calculation error.❌B. 150 mg→ Incorrect.Incorrect decimal placement.❌D. 15 g→ Incorrect.Overestimated.

????Reference:

USP <795>: Pharmaceutical Compounding – Nonsterile Preparations

PTCB Exam: Pharmaceutical Calculations

Aricept (Donepezil) is a cholinesterase inhibitorused for treatingmild, moderate, or severe Alzheimer's disease dementia.

Itworks by increasing acetylcholine levels in the brain, improving memory and cognitive function.

FDA-approved for all stages of Alzheimer’s disease.

B. Azilect❌→Used for Parkinson’s disease, not Alzheimer's.

Azilect (Rasagiline) is a monoamine oxidase-B (MAO-B) inhibitorthat helps manage Parkinson’s symptoms but is not indicated for dementia.

C. Ambien❌→Used for insomnia, not Alzheimer's dementia.

Ambien (Zolpidem) is a sedative-hypnotic for sleep disordersand does not treat cognitive decline.

D. Atacand❌→Used for hypertension, not dementia.

Atacand (Candesartan) is an angiotensin receptor blocker (ARB) used to treat high blood pressure and heart failure.

FDA Approved Uses for Donepezil (Aricept)– Confirms its indication for all stages of Alzheimer’s disease.

Alzheimer’s Association Treatment Guidelines– Listscholinesterase inhibitors as first-line therapy for dementia.

PTCB PTCE Exam Content Outline– Covers pharmacologic treatments for cognitive disorders.

Why Not the Other Options?Key References:

Risperidone (Risperdal oral solution)is anatypical antipsychoticused to treatschizophrenia, bipolar disorder, and autism-related irritability.

Itsoral liquid formulationmust be storedin the refrigerator (between 2°C and 8°C or 36°F to 46°F)to maintain stability.

If left at room temperature for an extended period, theactive ingredients can degrade, reducing the medication's effectiveness.

Storage Considerations for Other Medications:

Gabapentin (Neurontin liquid formulation):Must be refrigerated.✅

Sertraline (Zoloft oral solution):Stored at room temperature.❌

Aripiprazole (Abilify liquid formulation):Stored at room temperature.❌

????Reference:Manufacturer’s storage guidelines,USP Chapter <797>for compounded sterile preparations.

Briviact (brivaracetam) and Vimpat (lacosamide) are both anticonvulsantsused to treat epilepsy.

Therapeutic duplication alertswarn ofmultiple drugs treating the same condition, increasing the risk of side effects.

????Reference:ISMP Medication Safety Guidelines, PTCE Exam Study Guide.

ARisk Evaluation and Mitigation Strategy (REMS)program is required by theFDAfor certain medications that have serious safety concerns, ensuring their risks do not outweigh their benefits.Mycophenolateis subject to a REMS program due to its severe teratogenic effects.

(A) Sertraline❌Not Subject to REMS

Sertraline (Zoloft) is aSelective Serotonin Reuptake Inhibitor (SSRI)used to treat depression and anxiety.

While SSRIs can carry arisk of birth defects (such as persistent pulmonary hypertension in newborns - PPHN),sertraline is not included in the REMS program.

(B) Ondansetron❌Not Subject to REMS

Ondansetron (Zofran) is anantiemeticused to prevent nausea and vomiting.

While some studies suggest a possible increased risk of congenital defects, it isnot part of a REMS program.

(C) Montelukast❌Not Subject to REMS

Montelukast (Singulair) is aleukotriene receptor antagonist (LTRA)used forasthma and allergies.

It has aBoxed Warningfor mental health side effects butis not subject to a REMS program for pregnancy risks.

(D) Mycophenolate✅Correct – Subject to REMS

Mycophenolate (CellCept, Myfortic)is animmunosuppressantused to prevent organ rejection in transplant patients.

It carries ahigh risk of birth defects and miscarriage, making pregnancy preventionmandatorywhile taking the medication.

TheMycophenolate REMS Programrequires:

Mandatory counselingon pregnancy risks

Negative pregnancy testsbefore starting therapy

Use of effective contraceptionbefore, during, and after treatment

FDA REMS Program for

FDA REMS Program Overview:

PTCB Exam Content Outline – Medication Safety & Risk Management

Analysis of Answer Choices:References for Pharmacy Technicians:

Withdrawal occurs when a drug-dependent individual stops taking the drug abruptly, leading to physiological symptoms.

Example:Opioid withdrawal can cause nausea, sweating, and tremors.

Withdrawal differs from addiction, which involvescompulsive drug-seeking behavior.

????Reference:DEA Controlled Substance Abuse Guide, PTCE MedicationSafety Guidelines.

When abody area is exposed to a hazardous substance, thefirst actionshould be tothoroughly flush the area with watertoimmediately remove the contaminantand reduce absorption into the skin.

Flush the affected area with water for at least 15 minutes.

Remove contaminated clothing.

Seek medical attention if needed.

Report the incident to the pharmacy manager.

A. Notify the pharmacy manager→ Incorrect;the immediate priorityis to flush the area.Reporting comes after decontamination.

C. Call environmental services for cleanup→ Incorrect; personal exposure should be addressed before worrying about cleanup.

D. Go to the emergency department→ Incorrect; first aid (flushing with water) should beperformed immediatelybefore seeking additional care if necessary.

Proper Emergency Response:Other Answer Choices Explained:References:

USP <800> Guidelines for Handling Hazardous Drugs

OSHA (Occupational Safety and Health Administration) Hazardous Substance Exposure Protocols

PTCB PTCE Exam Content Outline (Medication Safety & Hazardous Drug Handling)

Carbon dioxide exposure can cause oxidation and degradation of certain medications, reducing theirstability and effectiveness.

????Reference:USP Drug Storage and Stability Guidelines.

Clopidogrel (Plavix) is an antiplatelet drug used to prevent blood clots, reducing the risk of heart attack (myocardial infarction) and stroke.

It is commonly prescribed afterstent placement, heart attack, or stroke.

Why Other Options Are Incorrect:

B. GERD?❌Treated withPPIs or H2 blockers(e.g., omeprazole, ranitidine).

C. Chronic migraines?❌Treated withbeta-blockers, triptans, or topiramate.

D. Type 2 diabetes?❌Treated withmetformin, insulin, or GLP-1 agonists.

????Reference:AHA Guidelines on Antiplatelet Therapy.

Comprehensive and Detailed Step-by-Step Explanation:

Mycophenolateis animmunosuppressantused inorgan transplantsand isteratogenic (causes birth defects).It requiresRisk Evaluation and Mitigation Strategies (REMS).

????Explanation of Answer Choices:✅B. Mycophenolate→Correct.High risk ofbirth defects, requiring REMS.❌A. Miconazole→ Incorrect.An antifungal with no REMS requirement.❌C. Phentermine→ Incorrect.Used for weight loss, not teratogenic.❌D. Phenytoin→ Incorrect.Has risks but no REMS requirement.

????Reference:

FDA REMS Program for Mycophenolate

PTCB Exam: Medication Safety & REMS

Comprehensive and Detailed Step-by-Step Explanation:

The FDA requires patient package inserts (PPIs) for certain medications, including oral contraceptives like norethindrone/ethinyl estradiol.

????Explanation of Answer Choices:

✅B. Norethindrone/Ethinyl Estradiol → Correct. Oral contraceptives must include a PPI with risk information.

❌A. Sulfamethoxazole/Trimethoprim → Incorrect. Does not require a package insert.

❌C. Triamterene/HCTZ → Incorrect. A diuretic, no required PPI.

❌D. Emtricitabine/Tenofovir Disoproxil → Incorrect. A PPI is required only for certain formulations.

????Reference:

FDA Patient Information Leaflet Requirements

Naproxen (Aleve, Naprosyn) is a nonsteroidal anti-inflammatory drug (NSAID) used for pain and inflammation.

????Reference:FDA NSAID Safety Guidelines.

Comprehensive and Detailed Step-by-Step Explanation:

Amedication erroroccurs when a patientreceives the wrong drug, dose, or administration method, which can result inadverse effects.High-risk medicationsinclude:

Injectable insulins(risk of hypoglycemia, coma).

Antineoplastic (chemotherapy) agents(toxic at incorrect doses).

Oral anticoagulants (e.g., warfarin, apixaban)(can causefatal bleeding).

????Explanation of Answer Choices:✅A. Topical creams→Correct.While topical medicationscan cause localized irritation or allergies, theyrarely cause systemic toxicitywhen used improperly.❌B. Injectable insulins→ Incorrect.Can cause life-threatening hypoglycemia.❌C. Antineoplastic agents→ Incorrect.High risk of toxicity and organ damage.❌D. Oral anticoagulants→ Incorrect.Incorrect dosing can lead to fatal bleeding.

????Reference:

ISMP List of High-Alert Medications

FDA Guidelines on Medication Errors

PTCB Exam: Medication Safety & Risk Management

Isotretinoin (Accutane) is regulated under the iPLEDGE program.

Only a 30-day supply is allowed, and pregnancy tests are required each month for females.

????Reference:FDA iPLEDGE Program, PTCB High-Risk Medication Guidelines.

In the providedcompounded prescription, the antifungal agent isnystatin.

Nystatin is a polyene antifungalthat works by binding toergosterolin fungal cell membranes, causing leakage of cellular contents and fungal cell death.

It iscommonly used for fungal infections, particularlycutaneous or mucosal Candida infections(e.g., diaper rash, oral thrush).

A. Cholestyramine.→ Incorrect. Cholestyramine is abile acid sequestrantused to lowercholesteroland treatdiarrhea(often in combination with other ingredients for skin irritation or wounds).

B. Hydrocortisone.→ Incorrect. Hydrocortisone is acorticosteroidused to reduceinflammation and itching, but it does not kill fungi.

C. Zinc oxide.→ Incorrect. Zinc oxide is askin protectantused fordiaper rash and minor burns, but it is not an antifungal.

Lexicomp Drug Database – Nystatin Mechanism of Action.

FDA Drug Label for Nystatin – Antifungal Properties.

PTCB PTCE Exam Content Outline – Compounded Preparations and Active Ingredients.

Mosby’s Pharmacy Technician: Principles and Practice – Dermatologic Compounding.

Why Is Nystatin an Antifungal?Why the Other Answer Choices Are Incorrect:Pharmacy Technician References:Conclusion:Pharmacy technicians must befamiliar with drug classificationsto correctly identify active ingredients incompounded prescriptions.Nystatin is the only antifungal agentin the provided formulation.

Cytoxan (cyclophosphamide)belongs to thechemotherapy agentdrug classification. It is analkylating agentused to treat various types ofcancer, including:

Leukemia

Lymphoma

Breast cancer

Ovarian cancer

It works byinterfering with DNA replication in rapidly dividing cells, preventing cancer growth.

A. ACE inhibitor❌→Incorrect

ACE inhibitors (angiotensin-converting enzyme inhibitors)are used forhypertension and heart failure(e.g., lisinopril, enalapril).

C. Antibiotic❌→Incorrect

Antibioticstreatbacterial infections(e.g., amoxicillin, azithromycin).

D. Narcotic❌→Incorrect

Narcotics (opioids) are pain relievers(e.g., morphine, oxycodone).Cytoxan is not an opioid.

National Cancer Institute (NCI) Drug Dictionary– ClassifiesCytoxan as an alkylating chemotherapy agent.

PTCB PTCE Exam Content Outline– Covers chemotherapy drugs and their classifications.

FDA Drug Classification Guidelines– Lists Cytoxan as acytotoxic antineoplastic (chemotherapy) drug.

Why Not the Other Options?Key References:

When adrug recalloccurs due totemperature excursions(exposure to temperatures outside the manufacturer’s recommended range during transport or storage), the pharmacy mustimmediately remove all affected productfrom its inventory to prevent dispensing compromised medication.

Remove the Affected Product:Quarantine the recalled drug to ensure it is not dispensed.

Verify the Recall Details:Confirm the lot number, expiration date, and reason for the recall using FDA or manufacturer recall notices.

Document the Recall Action:Log details in the pharmacy's recall records for compliance.

Follow Manufacturer or FDA Instructions:Some recalls require returning the product, while others require disposal according to hazardous waste guidelines.

Notify Patients and Providers (If Necessary):If the medication has already been dispensed, further action may be needed depending on recall severity.

B. Contact patients who received a therapeutically equivalent product.→ Incorrect. The recall applies to thespecificaffected lot, not all similar medications. Pharmacists would first verify which patients received the recalled drugbefore contacting them.

C. Switch patients from the oral solution to oral capsules.→ Incorrect. The recall does not automatically require a formulation change. The pharmacy must verify availability of unaffected stock or alternative treatments before making substitutions.

D. Contact all prescribers who recently prescribed the product.→ Incorrect. While prescribersmayneed notification if the recall affects patient treatment, thefirst stepis ensuring the recalled product is removed from stock to prevent further dispensing.

PTCB PTCE Exam Content Outline – Medication Safety and Recall Procedures.

FDA Drug Recall Guidelines

USP <1079> Good Storage and Distribution Practices for Pharmaceuticals.

National Association of Boards of Pharmacy (NABP) Recall Compliance Standards.

Manufacturer Recall Notices (Example: Pfizer, Eli Lilly, etc.).

Mosby’s Pharmacy Technician: Principles and Practice – Recall Classifications and Actions.

Steps to Follow in a Drug Recall:Why the Other Answer Choices Are Incorrect:Pharmacy Technician References:

Look-alike/sound-alike (LASA) medications are drugs that areeasily confused due to similar spelling or pronunciation, which increases the risk of medication errors.

Citalopram(Celexa) →Selective serotonin reuptake inhibitor (SSRI) used for depression

Celecoxib(Celebrex) →Nonsteroidal anti-inflammatory drug (NSAID) used for pain and inflammation

Why Are Citalopram and Celecoxib Considered LASA?Both drugs sharesimilar spelling and pronunciation, increasing the chance of errors inprescribing, dispensing, and administration.

Example of potential errors: A patient withdepressionmay mistakenly receiveCelecoxib (NSAID)instead ofCitalopram (antidepressant), leading to untreated depression and unnecessary NSAID use.

A. Lisinopril and Metoprolol❌→Different drug classes, butnot commonly confused.

Lisinopril(ACE inhibitor for blood pressure)

Metoprolol(Beta-blocker for blood pressure and heart conditions)

C. Acebutolol and Acetazolamide❌→Although their names look similar, they haveless common confusion in clinical practice.

Acebutolol(Beta-blocker)

Acetazolamide(Diuretic for glaucoma, altitude sickness)

D. Naproxen and Misoprostol❌→These are oftenprescribed togetherbut arenot confused with each other.

Naproxen(NSAID for pain)

Misoprostol(Used to protect the stomach from NSAID-induced ulcers)

Institute for Safe Medication Practices (ISMP) LASA List– ConfirmsCitalopram and Celecoxibas common look-alike/sound-alike drugs.

PTCB PTCE Exam Content Outline– Covers error prevention strategies, including LASA medications.

FDA Medication Error Prevention Guidelines– Recommends usingTall Man Lettering(e.g.,CeleXib vs. CitaloPram) to differentiate LASA drugs.

Why Not the Other Options?Key References:

Needlegauge (G)refers to thediameter of the needle’s lumen(opening).The higher the gauge number, the smaller the needle diameter.

Lower gauge (e.g., 13G, 18G)→Larger needle(wider opening)

Higher gauge (e.g., 27G)→Smaller needle(narrower opening)

Common Needle Gauges and Their Uses:Gauge (G)

Needle Diameter (mm)

Common Use

13G

2.4 mm

IV drug administration (large-bore)

18G

1.2 mm

Drawing thick medications (e.g., oil-based injections)

20G

0.9 mm

General intramuscular (IM) injections

27G

0.4 mm

Subcutaneous (SC) or intradermal (ID) injections (e.g., insulin, vaccines)

Since27Gis the highest gauge listed, it corresponds to thesmallestneedle diameter, making it the correct answer.

A. 13G❌→ One of the largest gauges, used for IV fluids or blood transfusions.

B. 18G❌→ Large needle used for thick medications likedepot injections or contrast agents.

C. 20G❌→ Common forintramuscular injectionsbut larger than 27G.

PTCB PTCE Exam Content Outline– Covers needle gauges, injection routes, and proper medication administration.

USP <797> & USP <800>– Provide sterile compounding guidelines, including appropriate needle gauge selection.

CDC Vaccine Administration Guidelines– Recommend25-30Gfor subcutaneous and intradermal injections.

Why Not the Other Options?Key References:

Comprehensive and Detailed Step-by-Step Explanation:

To preventheparin dosing errors, theFDA requires labeling to display:

Strength per total volume (e.g., 10,000 units/10 mL)

Strength per mL in parentheses (e.g., 1,000 units/mL)

????Explanation of Answer Choices:✅C. Strength per mL enclosed in parentheses→Correct.❌A. Percentage weight per volume→ Incorrect.Heparin is not measured this way.❌B. Volume per total strength→ Incorrect.Reverse order of required labeling.❌D. mL per dose enclosed in parentheses→ Incorrect.Dosing varies by prescription.

????Reference:

FDA Heparin Labeling Guidelines

Lipitor is the brand name forAtorvastatin, aHMG-CoA reductase inhibitor (statin)used to lower cholesterol and reduce the risk of cardiovascular disease.

(A) Provastatin❌Incorrect –Misspelled, should bePravastatin(Pravachol).

(B) Fluvastatin❌Incorrect – Fluvastatin (Lescol) is another statin, but not the generic for Lipitor.

(C) Simvastatin❌Incorrect – Simvastatin (Zocor) is a statin but not the generic for Lipitor.

(D) Atorvastatin✅Correct – The generic name for Lipitor.

Analysis of Answer Choices:Statins & Their Brand Names:Generic Name

Brand Name

Atorvastatin

Lipitor✅

Simvastatin

Zocor

Pravastatin

Pravachol

Fluvastatin

Lescol

Rosuvastatin

Crestor

Lovastatin

Mevacor

Lipitor Prescribing Information:

PTCB Exam Content Outline – Generic & Brand Name Drug Recognition

Pharmacology for Pharmacy Technicians, 3rd Edition – Perspective on Statin Medications

References for Pharmacy Technicians:

Experiencingphotosensitivity(increased sensitivity to sunlight) as a result of takingciprofloxacinis an example of anadverse drug reaction (ADR). Thisunexpectedandundesirableeffect occurs in some individuals due tofluoroquinolones causing cellular damage from UV exposure.

A. Intended effect→ Incorrect; the intended effect of ciprofloxacin isbacterial infection treatment, not photosensitivity.

C. Synergistic effect→ Incorrect; asynergistic effectoccurs whentwo drugs work togetherto produce a greater effect, which is not the case here.

D. Anaphylactic reaction→ Incorrect;anaphylaxisis asevere allergic reactionwithrespiratory distress, hypotension, and swelling, not photosensitivity.

Other Answer Choices Explained:References:

PTCB PTCE Exam Content Outline (Medication Safety & Side Effects)

Lexicomp Drug Monograph for Ciprofloxacin

FDA Fluoroquinolone Safety Warnings

????Reference:PTCE Medication Usage Calculations.

AClass III recallis issued whena drug is unlikely to cause adverse health effects but has a labeling defect, packaging issue, or a minor violation of manufacturing regulations.

Example:A bottle of tablets with a slightly misprinted label.

Pharmacies must remove affected stock but are NOT required to notify patients or physicians.

Why Other Options Are Incorrect:

A. Posting signs?❌Only required for certain urgent recalls.

C. Notifying physicians?❌Required forClass I and some Class II recalls, not Class III.

D. Contacting patients?❌Not needed fornon-health-threatening recalls.

????Reference:FDA Drug Recall Guidelines, PTCE Exam Study Guide.

Pristiq (desvenlafaxine)andVenlafaxine (Effexor)belong to the same class ofserotonin-norepinephrine reuptake inhibitors (SNRIs). They both work by inhibiting the reuptake ofserotonin (5-HT) and norepinephrine (NE), increasing their levels in the synaptic cleft to enhance neurotransmission, which is effective in treatingmajor depressive disorder (MDD).

A. Valacyclovir→ Incorrect; valacyclovir is anantiviralused to treatherpes simplex and varicella-zoster infections.It inhibits viral DNA replication, not neurotransmitter reuptake.

B. Varenicline→ Incorrect; varenicline (Chantix) is apartial nicotinic receptor agonistused forsmoking cessation, not an SNRI.

D. Verapamil→ Incorrect; verapamil is acalcium channel blocker (CCB)used forhypertension and arrhythmias, which has no relation to antidepressant mechanisms.

Other Answer Choices Explained:References:

PTCB PTCE Exam Content Outline (Pharmacology for Technicians – Nervous System Drugs)

Lexicomp Drug Monographs for Desvenlafaxine and Venlafaxine

Goodman & Gilman’s The Pharmacological Basis of Therapeutics

AUstands for"auris utraque", meaning"both ears".✅

Sig codes (Signa codes)are abbreviations used in prescriptions to indicate how a medication should be taken or applied.

Why Other Options Are Incorrect:

q.s. (quantum satis):Means "a sufficient quantity," NOT"shake well."❌

IN:Refers tointranasal, NOTintramuscular (IM).❌

q.i.d. (quater in die):Means"four times a day,"NOT"three times a day".❌

????Reference:PTCB Official Sig Code List,Institute for Safe Medication Practices (ISMP) Approved Abbreviations.

Lamivudine (Epivir)is anantiretroviral agent used to treat HIV/AIDS and hepatitis B. Some antiretroviral drugs are classified ashigh-alert medications in certain healthcare settingsbecause:

Dosing errors can lead to treatment failure or resistance.

Severe side effects and toxicities may occur if misused.

TheInstitute for Safe Medication Practices (ISMP)includes some antiretrovirals in theirhigh-alert medication list, especially in hospitals.

A. Meperidine❌→Not an antiretroviral; it's a narcotic analgesic (opioid pain reliever).

B. Olopatadine❌→Not an antiretroviral; it's an antihistamine (used for allergies).

D. Tizanidine❌→Not an antiretroviral; it's a muscle relaxant.

ISMP High-Alert Medication List– Includes certainantiretroviral drugs as high-alert medications in some settings.

FDA Drug Labeling for Lamivudine (Epivir)– ListsHIV/AIDS and Hepatitis B as indications.

PTCB PTCE Exam Content Outline– Covers high-alert medications and their risks.

Why Not the Other Options?Key References:

ANarrow Therapeutic Index (NTI) drugis a medication in whichsmall differences in dose or blood concentrationcan lead to serioustoxicityorsubtherapeutic effects. These drugs requirecareful dosing and monitoringto avoid adverse effects or treatment failure.

Small Margin of Safety:The difference between theminimum effective concentration (MEC)and theminimum toxic concentration (MTC)is very narrow.

Requires Therapeutic Drug Monitoring (TDM):Blood levels of the drug must be regularly monitored to maintain efficacy while avoiding toxicity.

High Risk of Adverse Effects:Even minor dosage adjustments or variations in patient metabolism can cause toxicity.

Strict Pharmacokinetic and Pharmacodynamic Considerations:Factors likerenal and hepatic function, drug interactions, and patient weightsignificantly impact the drug’s effect.

Warfarin (Coumadin) → Risk of bleeding.

Digoxin → Risk of toxicity affecting the heart.

Phenytoin → Risk of severe neurological effects.

Levothyroxine → Risk of under- or over-treatment of thyroid disorders.

Theophylline → Risk of respiratory or cardiac toxicity.

Carbamazepine → Risk of serious neurological side effects.

A. Shorter window of guaranteed stability.→ Incorrect. NTI drugs do not necessarily have a shorter shelf-life or stability concerns compared to other drugs. Stability depends on formulation and storage conditions.

B. Incompatibility with therapeutic monitoring.→ Incorrect. NTI drugsrequiretherapeutic monitoring, not the opposite.

C. Synergistic effect on other medications.→ Incorrect. While NTI drugs can interact with other drugs, not all exhibit a synergistic effect (where combined drugs produce a greater effect than expected).

PTCB PTCE Exam Content Outline – Medication Safety and Quality Assurance(Monitoring NTI drugs).

FDA Narrow Therapeutic Index Drug List(Guidelines on NTI medications).

Lexicomp and Micromedex Drug Databases(Provide monitoring recommendations for NTI drugs).

USP <800> Hazardous Drugs and USP <797> Sterile Compounding Guidelines(Ensure safe handling and dispensing of NTI drugs).

Mosby’s Pharmacy Technician: Principles and Practice(NTI drug classification and monitoring).

Key Characteristics of NTI Drugs:Examples of NTI Drugs:Why the Other Answer Choices Are Incorrect:Pharmacy Technician References:

Comprehensive and Detailed Step-by-Step Explanation:

Alot number (or batch number)is aunique identifierassigned to a specific batch of medication by themanufacturer. It helps trackrecalls, expiration dates, and quality control.

????Explanation of Answer Choices:✅D. Manufacturer→Correct.Manufacturers assignlot numbersfor tracking and recall purposes.❌A. FDA→ Incorrect. TheFDA does not assign lot numbersbut regulatesdrug safety and labeling.❌B. DEA→ Incorrect. TheDEA controls controlled substancesbut does not issuelot numbers.❌C. Wholesaler→ Incorrect.Wholesalers distribute drugs but do not assign lot numbers.

????Reference:

FDA Drug Product Recall Guidelines

PTCB Inventory Management Section

TheVaccine Adverse Event Reporting System (VAERS)is a national system managed by theCDC and FDAto monitoradverse events following vaccination.

Anaphylaxisis asevere, life-threatening allergic reactionthat must beimmediately reported to VAERS, as it is a known but rareserious vaccine side effect.

Other serious events likeGuillain-Barré syndrome, myocarditis, and seizuresalso require VAERS reporting.

A. Constipation→ Incorrect;not a serious vaccine-related event.

C. Drowsiness→ Incorrect; commonbut not severeenough to require VAERS reporting.

D. Hyperlipidemia→ Incorrect;unrelated to vaccines.

Other Answer Choices Explained:References:

CDC VAERS Reporting Criteria for Adverse Vaccine Reactions

FDA Vaccine Safety Monitoring Guidelines

PTCB PTCE Exam Content Outline (Immunizations & Adverse Drug Event Reporting)

PerUSP standards, a drug with an expiration date ofMarch 2025is consideredvalid until the last day of the month, which isMarch 31, 2025. This applies unless otherwise specified by the manufacturer.

If a drug is labeledMM/YYYY, itremains valid until the last day of that month.

If a drug is labeled with aspecific day (MM/DD/YYYY), itexpires at the end of that day.

A. February 28, 2025→ Incorrect; the expiration is at the end ofMarch, not February.

B. March 1, 2025→ Incorrect; the drug is stillusable until March 31.

D. March 1, 2026→ Incorrect; the drugexpires in March 2025, not 2026.

Expiration Date Rules:Other Answer Choices Explained:References:

USP <797> Pharmaceutical Compounding – Expiration and Beyond-Use Dating (BUD) Guidelines

FDA Drug Expiration Date Regulations

PTCB PTCE Exam Content Outline (Pharmaceutical Storage & Stability)

To calculate how muchamoxicillin suspensionwill be used in the first5 days, we follow these steps:

Amoxicillin concentration:250 mg per5 mL

Dosage:1 tsp (5 mL) three times daily (tid)

Duration:First5 days

Step 1: Identify Given InformationStep 2: Calculate Total Daily Volume5 mL×3=15 mL per day5 \text{ mL} \times 3 = 15 \text{ mL per day}5 mL×3=15 mL per day

Step 3: Multiply by 5 Days15 mL/day×5 days=75 mL15 \text{ mL/day} \times 5 \text{ days} = 75 \text{ mL}15 mL/day×5 days=75 mL

Thus, the patient will use75 mLof medication in the first5 days.

A. 25 mL→ Incorrect; this would be correct if taken onlyonce dailyinstead ofthree times daily.

B. 50 mL→ Incorrect; this is the correct amount for3.3 days, not 5 days.

D. 150 mL→ Incorrect; this is thefull 10-day course, not just the first 5 days.

Other Answer Choices Explained:References:

PTCB PTCE Exam Content Outline (Pharmaceutical Calculations – Dosage & Volume Calculations)

USP <795> Nonsterile Compounding Guidelines

Lexicomp Drug Monograph for Amoxicillin Suspension

According toUSP <800>andOSHA guidelines, exposure control forhazardous drugs (HDs)must begin as soon as the drugenters the facilityto ensure proper handling, storage, and administration safety. This includes:

Receiving:

Hazardous drugs must beunpacked in a designated areathat isseparate from regular medications.

They shouldnot be opened in sterile or positive-pressure areasto prevent contamination.

Storage:

HDs must be stored in anegative-pressure room with proper ventilation.

They must be placed indesignated binsto reduce exposure risks.

Handling and Compounding:

Usepersonal protective equipment (PPE)such as gloves, gowns, and masks when handling hazardous drugs.

Use abiological safety cabinet (BSC) or compounding aseptic containment isolator (CACI)when preparing hazardous drugs.

A. Is dispensed→ Incorrect;control measures must start earlier, before dispensing.

C. Is compounded→ Incorrect; safety measures beginbefore compounding, when the drug arrives at the pharmacy.

D. Is placed on the pharmacy shelf→ Incorrect;exposure control measuresbegin before storage, duringreceiving and handling.

Other Answer Choices Explained:References:

USP <800> Hazardous Drug Handling Guidelines

OSHA Hazardous Drug Safety Standards

NIOSH (National Institute for Occupational Safety and Health) Hazardous Drug List

PTCB PTCE Exam Content Outline (Medication Safety & Hazardous Drug Handling)

According tofederal law(Controlled Substances Act, CSA) andDrug Enforcement Administration (DEA) regulations, a prescription for aSchedule III or IV controlled substancemay be refilleda maximum of five (5) times within six (6) monthsfrom the date the prescription was written.

Refill Limit:A Schedule IV prescription may be refilled up to five (5) times within six (6) monthsfrom the issue date, if authorized by the prescriber.

Expiration:The prescription expiressix (6) monthsafter the date it was written.

Recordkeeping:The pharmacy must maintain accurate refill records either electronically or manually.

Additional Refills Beyond 5:If the patient needs refills after the 5-refill limit, anew prescriptionmust be issued by the prescriber.

Partial Fills:Partial dispensing is allowed, but the total quantity dispensed cannot exceed the originally prescribed amount.

A. 2 times in 3 months.→ Incorrect. Federal law allows more than 2 refills for Schedule IV drugs.

B. 3 times in 4 months.→ Incorrect. This underestimates the legal refill limit.

C. 4 times in 6 months.→ Incorrect. Schedule IV drugs may be refilledup to 5 times, not just 4, within 6 months.

DEA Pharmacist’s Manual – Controlled Substances Act (21 CFR 1306.22).

PTCB PTCE Exam Content Outline – Federal Pharmacy Law and Controlled Substances.

FDA and DEA Guidelines on Schedule III-V Prescription Refills.

Mosby’s Pharmacy Technician: Principles and Practice – Controlled Substances Regulations.

Key DEA Rules for Schedule III and IV Prescriptions:Why the Other Answer Choices Are Incorrect:Pharmacy Technician References:

Pharmacy staff should always visually inspect nonsterile compounds for signs of incompatibility to ensure medication safety and efficacy. The presence ofprecipitationis a key indicator of an incompatibility issue in nonsterile compounded preparations. Precipitation occurs when a solute (drug) comes out of solution, forming visible solid particles. This can result from changes in pH, solvent composition, or chemical interactions between ingredients.

A. Photolysis:

Decomposition of a drug due to light exposure, leading to color changes or potency loss, but it is not a physical incompatibility visible as precipitation.

B. Hydrolysis:

Chemical breakdown of a drug due to water, common in ester and amide-containing drugs, but not a visual incompatibility like precipitation.

D. Oxidation-Reduction:

A chemical reaction that may change drug color or effectiveness but does not typically lead to visible precipitation in nonsterile compounds.

Other Answer Choices Explained:References:

USP <795> Pharmaceutical Compounding—Nonsterile Preparations

PTCB PTCE Exam Content Outline (Medication Safety & Quality Assurance)

Remington: The Science and Practice of Pharmacy

Pharmacy technicians help patients adhere to medication regimens by scheduling refills, promoting medication synchronization, and assisting with adherence packaging.

????Reference:PTCB Medication Adherence Guidelines, Pharmacy Technician Role in Patient Care.

Comprehensive and Detailed Step-by-Step Explanation:

Desvenlafaxine (Pristiq)is anSNRI (Serotonin-Norepinephrine Reuptake Inhibitor)used to treatmajor depressive disorder (MDD).

????Explanation of Answer Choices:✅B. Major depressive disorder→Correct.Desvenlafaxine is FDA-approved fordepression.❌A. Hypertension→ Incorrect.Not an antihypertensive.❌C. Benign prostatic hypertrophy→ Incorrect.Alpha-blockers like Tamsulosin treat BPH.❌D. Atrial fibrillation→ Incorrect.Beta-blockers, not SNRIs, manage atrial fibrillation.

????Reference:

FDA Drug Database: Desvenlafaxine

PTCB Exam: Pharmacology for Technicians

Comprehensive and Detailed Step-by-Step Explanation:

Adsorption occurs when a drug binds to a surface (e.g., IV tubing), reducing its potency.Some drugs, likeinsulin and nitroglycerin,canadhere to plastic tubing, reducing the active dose the patient receives.

????Explanation of Answer Choices:✅A. Lose potency→Correct.Adsorptionreduces drug strength.❌B. Become contaminated→ Incorrect.Adsorption does not introduce contaminants.❌C. Require refrigeration→ Incorrect.Refrigeration is unrelated to adsorption.❌D. Trigger anaphylaxis→ Incorrect.Adsorption does not cause allergic reactions.

????Reference:

USP <797>: Sterile Compounding

ISMP Guidelines on IV Drug Stability

Pharmacy technicians in certain states may initiate the transfer of non-controlled prescriptions under pharmacist supervision.

Controlled substance transfers MUST be done by pharmacists.

????Reference:State Board of Pharmacy Regulations.

Comprehensive and Detailed Step-by-Step Explanation:

Ahazardous drug spill kitisrequiredunderUSP <800>, which outlinessafe handling practices for hazardous drugs (HDs). The kit must contain:

Disposable scoop and scraper(to safely collect broken glass and contaminated material).

Absorbent pads or spill control pillows(for liquid spills).

Chemotherapy-rated gloves, gown, goggles, and mask(for protection).

A hazardous waste disposal bag(to properly dispose of contaminated materials).

????Explanation of Answer Choices:✅D. A disposable scoop for glass fragments→Correct.Adisposable scoop is essentialto safely removehazardous drug spills containing broken glass.❌A. Permeable, disposable protective garments→ Incorrect. PPE for hazardous drug spills must beimpermeable(e.g., coated gowns).❌B. Sufficient supplies to absorb a spill of about 10,000 mL→ Incorrect.Most spill kits are designed for smaller spills (≤1000 mL), not massive industrial spills.❌C. Reusable absorbent sponges or toweling→ Incorrect.All absorbent materials must be disposable to prevent contamination.

????Reference:

USP <800>: Handling Hazardous Drugs in Healthcare Settings

NIOSH List of Hazardous Drugs (2020 Update)

PTCB Exam: Medication Safety & Hazardous Drug Management

5-FU (Fluorouracil) is a chemotherapy drugused forcolon, breast, and skin cancers.

It is apyrimidine analogthatprevents cancer cell DNA replication.

Why Other Options Are Incorrect:

A. Fluocinonide?❌Topical corticosteroid for skin conditions.

B. Fluoxetine (Prozac)?❌SSRI antidepressant.

C. Fluocinolone?❌Topical corticosteroid.

????Reference:National Cancer Institute Chemotherapy Guide, PTCB Oncology Medications.

Root-Cause Analysis (RCA)is asystematic processused inhealthcare and pharmacy settingstoidentify the underlying factors that contributed to an error or safety event. RCA helps pharmacy staff determinewhy a problem occurredand implement corrective actions toprevent future occurrences.

Identify the problem or event.

Gather and analyze data.

Determine the root cause(s).

Develop and implement corrective actions.

Monitor for improvement and prevention of recurrence.

A. Determine which medication should be dispensed→ Incorrect; RCA is focused onerror investigation, not routine dispensing decisions.

B. Decipher prescriber handwriting during order entry→ Incorrect; this is not the purpose of RCA, though poor handwriting may be identified as a contributing factor in an error.

C. Increase pharmacy revenue and inventory turnover→ Incorrect; RCA is aboutpatient safety and error prevention, not financial performance.

Steps in Root-Cause Analysis (RCA):Other Answer Choices Explained:References:

ISMP (Institute for Safe Medication Practices) RCA Guidelines

FDA Medication Error Prevention Strategies

PTCB PTCE Exam Content Outline (Quality Assurance & Medication Safety)

Arashis acommon allergic reactionto medications.Drug allergiesoccur when the immune system overreacts to a medication, leading to symptoms such as:

Skin rash (most common)

Hives (urticaria)

Swelling (angioedema)

Anaphylaxis (severe reaction)

A. Dizziness❌→Side effect, not an allergic reaction.

Some medications (e.g., antihypertensives) cause dizziness, but it isnot an immune system response.

B. Constipation❌→Side effect, not an allergic reaction.

Opioids (e.g., morphine, oxycodone) commonly cause constipation, but it isnot due to an allergy.

C. Nausea❌→Side effect, not an allergic reaction.

Many medications (e.g., antibiotics, chemotherapy) cause nausea, but this isnot an immune-mediated reaction.

American Academy of Allergy, Asthma & Immunology (AAAAI)– Defines allergic reactions to medications.

FDA Drug Allergy Guidelines– Lists common symptoms of drug allergies.

PTCB PTCE Exam Content Outline– Covers adverse drug reactions and medication safety.

Why Not the Other Options?Key References:

Oxybutynin (Ditropan, Oxytrol)is ananticholinergic/antispasmodicmedication thatrelaxes the bladder musclesto treatoveractive bladder (OAB).

It reduces symptoms such asfrequent urination, urgency, and urinary incontinenceby blockingmuscarinic receptorsthat control bladder contractions.

Why Other Options Are Incorrect:

A. Bronchitis?❌No, bronchitis is treated withbronchodilators, steroids, or antibiotics.

B. Hyperlipidemia?❌No, hyperlipidemia (high cholesterol) is treated withstatins (e.g., atorvastatin).

D. Pancreatitis?❌No, pancreatitis is managed withIV fluids, pain control, and pancreatic enzyme therapy.

????Reference:FDA Oxybutynin Drug Label, Pharmacology of Urinary Anticholinergics.

During pregnancy, medication safety is classified by theFDA Pregnancy Categories(prior to 2015) or thePregnancy and Lactation Labeling Rule (PLLR)(current system).

Acetaminophen (Tylenol) is considered the safest analgesic for pregnant women, especially for treating mild to moderate pain or fever.

It hasno known teratogenic effectswhen used at recommended doses.

A. Isotretinoin❌→Severe risk in pregnancy (Category X / Contraindicated)

Causes severe birth defects(craniofacial, cardiac, and central nervous system malformations).

Requires enrollment in theiPLEDGE programto prevent pregnancy exposure.

C. Lovastatin❌→Not safe in pregnancy (Category X / Contraindicated)

Cholesterol-lowering statins are teratogenic, as fetal development requires cholesterol.

D. Triazolam❌→Not safe in pregnancy (Category X / Contraindicated)

A benzodiazepine that can cause birth defects, neonatal withdrawal syndrome, and CNS depression in the fetus.

FDA Pregnancy and Lactation Labeling Rule (PLLR)– Discusses medication risks in pregnancy.

American College of Obstetricians and Gynecologists (ACOG) Guidelines– Listsacetaminophen as the preferred pain reliever during pregnancy.

PTCB PTCE Exam Content Outline– Covers drug safety in special populations, including pregnancy.

Why Not the Other Options?Key References:

Comprehensive and Detailed Step-by-Step Explanation:

Acetaminophen (Tylenol)is metabolized by theliver.Excessive doses or concurrentalcohol useincreases the risk ofliver damage (hepatotoxicity).

????Explanation of Answer Choices:✅D. Alcoholic beverages→Correct. Alcohol and acetaminophen together can causesevere liver damage.❌A. Citrus fruits→ Incorrect. Citrus does not interfere withacetaminophen metabolism.❌B. Leafy greens→ Incorrect. Leafy greens affectwarfarin, notacetaminophen.❌C. Dairy products→ Incorrect. Dairy does not interact withacetaminophen.

????Reference:

FDA Acetaminophen Warnings

PTCB Medication Safety Guidelines

Grapefruit juice inhibits CYP3A4 enzymes, increasingbudesonide levels inthe blood, leading tohigher risk of side effects (immune suppression, adrenal insufficiency).

Budesonide is a corticosteroid used for Crohn’s disease and asthma.

Why Other Options Are Incorrect:

B. Dairy products?❌No significant interaction.

C. Leafy greens?❌Affectswarfarin (not budesonide).

D. Aged cheese?❌Interacts withMAO inhibitors, not budesonide.

????Reference:FDA Drug-Food Interaction Guide, PTCB Medication Safety Guidelines.

ISMP MERP (Institute for Safe Medication Practices – Medication Error Reporting Program)allows healthcare professionals toreport medication errorsto improve patient safety.

Common errors reported:

Incorrect medication dispensing

Wrong dosages

Look-alike, sound-alike drug errors

????Reference:ISMP Official Medication Error Guidelines.

Comprehensive and Detailed Step-by-Step Explanation:

TheDEA (Drug Enforcement Administration) mandates that controlled substance records must be kept for at least 2 years.

????Explanation of Answer Choices:✅B. 2 years→Correct.TheControlled Substances Act (CSA) requires pharmacies to maintain records for at least 2 years.❌A. 1 year→ Incorrect.Too short.❌C. 5 years→ Incorrect.Some states require longer retention, but federal law states 2 years.❌D. 7 years→ Incorrect.Not required by federal law.

????Reference:

DEA Controlled Substances Act (21 CFR § 1304.04)

PTCB Exam: Pharmacy Law & Regulations

Comprehensive and Detailed Step-by-Step Explanation:

Hand hygiene is the single most effective way to prevent infection.Washing hands withsoap and water for at least 30 secondsremoves bacteria, viruses, and contaminants.

????Explanation of Answer Choices:✅D. Wash hands for 30 seconds→Correct.Best method toreduce the spread of infection.❌A. Wear powdered latex gloves→ Incorrect.Powdered gloves can increase contamination risk.❌B. Clean counting trays after use→ Incorrect.Important, but handwashing is more effective.❌C. Put on shoe covers→ Incorrect.Useful in sterile environments, but not as effective as handwashing.

????Reference:

CDC Hand Hygiene Guidelines

USP <797>: Infection Control in Pharmacies

The NDC number (National Drug Code) is the most effective way to ensure the correct drug is selected.

Hydralazine (blood pressure medication) and hydroxyzine (antihistamine) are Look-Alike, Sound-Alike (LASA) drugsthat can cause serious medication errors if mixed up.

????Reference:ISMP LASA Guidelines, FDA NDC Number Verification.

MedWatch is the FDA’s reporting system for adverse drug events, medication errors, and safety concerns.

????Reference:FDA MedWatch Program.

Diflucan (Fluconazole) is an antifungal medicationused to treatsystemic and local fungal infections, including:

Candidiasis (oral thrush, vaginal yeast infections)

Cryptococcal meningitis

Fungal infections in immunocompromised patients (HIV/AIDS, chemotherapy patients, etc.)

Fluconazole works byinhibiting fungal ergosterol synthesis, which is essential for fungal cell membrane integrity.

A. Bacterial infections❌→Incorrect

Fluconazole does NOT treat bacterial infections; antibiotics are required instead.

B. Gastroesophageal reflux disease (GERD)❌→Incorrect

Proton pump inhibitors (PPIs) or H2 blockers(e.g., omeprazole, ranitidine) are used for GERD.

C. Altitude sickness❌→Incorrect

Acetazolamide (Diamox) is used for altitude sickness, not fluconazole.

FDA Fluconazole Drug Label– Confirms antifungal indications.

Centers for Disease Control and Prevention (CDC) Guidelines– Lists fluconazole asa treatment for candidiasis and cryptococcal meningitis.

PTCB PTCE Exam Content Outline– Covers antifungal medications and their indications.

Why Not the Other Options?Key References:

To determine the total number of10 mg prednisone tabletsrequired to fill the prescription, let's break it down by daily dosing:

First 2 days→ 20 mgtwice daily(b.i.d) =40 mg per day

Total for 2 days:40 mg × 2 =80 mg

Next 2 days→ 20 mgonce daily=20 mg per day

Total for 2 days:20 mg × 2 =40 mg

Next 2 days→ 10 mgonce daily=10 mg per day

Total for 2 days:10 mg × 2 =20 mg

Final 2 days→ 5 mgonce daily=5 mg per day

Total for 2 days:5 mg × 2 =10 mg

Days 1–4:(20 mg doses) → Each 20 mg dose requirestwo 10 mg tablets

Total for these 4 days:(20 mg × 4 days) = 80 mg

Tablets required:80 mg ÷ 10 mg =8 tablets

Days 5–6:(10 mg doses) → Each day requiresone 10 mg tablet

Total for these 2 days:10 mg × 2 =20 mg

Tablets required:20 mg ÷ 10 mg =2 tablets

Days 7–8:(5 mg doses) → Each day requireshalf of a 10 mg tablet

Total for these 2 days:5 mg × 2 =10 mg

Tablets required:1 full tablet (split into halves for two doses)

Step 1: Understanding the Prescription DirectionsStep 2: Determining the Number of 10 mg Tablets NeededFinal Calculation:8 tablets (Days 1-4) + 2 tablets (Days 5-6) + 1 tablet (Days 7-8) = 15 tablets

PTCB PTCE Exam Content Outline– Covers dosage calculations, unit conversions, and prescription interpretation.

Basic Pharmacy Math Principles– Ensuring proper medication dispensing based on prescription instructions.

Pharmacy Practice Guidelines– Proper dispensing techniques for titration therapy, such as steroid tapering.

Key References: